Publications

Middleton EJ, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 52(4): 673-751, 2000.

Donelan J, Papadopoulou N, Marchand J, Kempuraj D, Lytinas M, Boucher W, Papaliodis D, Theoharides TC. Corticotropin-releasing hormone (CRH) induces skin vascular permeability through a neurotensin (NT)- dependent process. Proc Natl Acad Sci USA 103:7759-7764. 2006.

Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45(11):2179-205, 2007.

Kempuraj D, Tagen M, Iliopoulou BP, Clemons A, Vasiadi M, Boucher W, House M, Wolferg A, Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell dependent stimulation of Jurkat T cells. Br J Pharmacol 155(7): 1076-1084, 2008.

Theoharides TC , Doyle R. Autism, gut-blood-brain barrier and mast cells. J Clin Psychopharm 28(5): 479-483, 2008.

Jang S, Kelley KW, Johnson RW.Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A 27;105(21):7534-9, 2008.

Parker-Athill E, Luo D, Bailey A, Giunta B, Tian J, Shytle RD, Murphy T, Legradi G, Tan J. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. J Neuroimmunol 217(1-2): 20-27, 2009.

Angelidou A, Francis K, Vasiadi M, Alysandratos K-D, Zhang B, Theoharides A, Lykouras L, Kalogeromitros D, Theoharides T. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflam 7: 48, 2010.

Angelidou A, Francis K, Vasiadi M, Alysandratos KD, Zhang B, Theoharides A, Lykouras L, Sideri K, Kalogeromitros D, Theoharides TC. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflammation 7:48, 2010.

Zhang BD, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi. S, Theoharides A, Sideri K, Lykouras L, Kalogeromitros D, Theoharides TC, Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. J Neuroinflammation 7(1):80, 2010.

Theoharides TC , Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P.IL-33 augments substance P-induced VEGFsecretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci USA 107(9):4448-53, 2010.

Careaga M, Van de Water J, Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics

7(3):283-92, 2010.

Fox E, Amaral D, Van de Water J. Maternal and fetal antibrain antibodies in development and disease. Dev Neurobiol 72(10):1327-34, 2012.

Zhang B, Alysandratos KD, Angelidou A, Asadi S, Sismanopoulos N, Delivanis D-A, Weng Z, Miniati A, Vasiadi M, Katsarou-Katsari A, Miao B, Leeman S, Kalogeromitros D, Theoharides TC. Human mast cell degranulation andgranule-stored TNF secretion requires mitochondrial translocation to sites of exocytosis. J Allergy Clin Immunol 127(6):1522-1531.e8, 2011.

Jäger AK, Saaby L. Flavonoids and the CNS. Molecules 16(2):1471-85, 2011.

Braunschweig D, Van de Water J. Maternal autoantibodies in autism. Arch Neurol 69(6):693-9, 2102.

Angelidou A, Alysandratos K-D, Asadi S, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk for autism. BMC Pediatrics 12:89, 2012.

Vasiadi M, Therianou A, Sideri K, Smyrnioti M, Delivani D, Sismanopoulos N, Asadi S, Katsarou-Katsari A, Petrakopoulou D, Theoharides A, Antoniou C, Stavrianeas N, Kalogeromitros D, Theoharides TC. Increased serum CRH levels with decreased skin CRH-R1 gene expression in psoriasis and atopic dermatitis, J Allergy Clin Immunol 129(5):1410-3, 2012.

Zhang B, Asadi S , Weng Z, Sismanopoulos N, Theoharides TC.Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions. PloS One 7(12):e49767, 2012.

Theoharides TC , Asadi S, Patel AB. Focal brain inflammation and autism. J Neuroinflammation 10:46, 2013.

Theoharides TC, Asadi S, Panagiotidou S. A case series of a luteolin formulation (NeuroProtek) on autism spectrum disorders. Int J Immunopathol Pharmacol 25(2): 317-323, 2012.

Theoharides TC. Is a subtype of autism "allergy of the brain"? Clin Ther 35(5): 584-591, 2013.

Theoharides TC , Asadi S, Panagiotidou S, Weng Z. The "missing link" in autoimmunity and autism: Extracellularmitochondrial components secreted from activated live mast cells. Autoimmun Rev 12:1136-1142, 2013.

Taliou A, Zintzaras E, Lykouras L, Francis K. An open-label pilot study of a formulation containing the anti- inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther 35(5): 592-602, 2013.

Immunological and autoimmune considerations of Autism Spectrum Disorders. Gesundheit B, Rosenzweig JP, Naor D, Lerer B, Zachor DA, Procházka V, Melamed M, Kristt DA, Steinberg A, Shulman C, Hwang P, Koren G, Walfisch A, Passweg JR, Snowden JA, Tamouza R, Leboyer M, Farge-Bancel D, Ashwood P. J Autoimmun 44:1-7, 2013.

Goines PE, Ashwood P.Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol 36:67-81, 2013.

Mostafa GA, Al-Ayadhi LY.The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children. J Neuroimmunol 15;261(1-2):77-81, 2013.

Kritas SK, Saggini A, Varvara G, Murmura G, Caraffa A, Antinolfi P, Toniato E, Pantalone A, Neri G, Frydas S, Rosati M, Tei M, Speziali A, Saggini R, Pandolfi F, Cerulli G, Theoharides TC, Conti P. Luteolin inhibits mast cell- mediated allergic inflammation. J Biol Regul Homeost Agents 27(4):955-9, 2013.

Skefos J, Cummings C, Enzer K, Holiday J, Weed K, Levy E, Yuce T, Kemper T, Bauman M.Regional alterations in purkinje cell density in patients with autism. PLoS One 9(2):e81255, 2014.

Herbert MR, Buckley JA. Autism and dietary therapy: case report and review of the literature. J Child Neurol 28(8):975-82, 2013.

Theoharides TC, Asadi S, Panagiotidou S, Weng Z.The "missing link" in autoimmunity and autism: extracellularmitochondrial components secreted from activated live mast cells. Autoimmun Rev 12(12):1136-42, 2013.

Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 4:e360, 2014.

Theoharides TC, Conti P, Economu M.Brain inflammation, neuropsychiatric disorders, and immunoendocrine effects of luteolin. J Clin Psychopharmacol 34(2):187-9, 2014.

Bauman MD, Iosif AM, Smith SE, Bregere C, Amaral DG, Patterson PH.Activation of the maternal immune systemduring pregnancy alters behavioral development of rhesus monkey offspring. Biol Psychiatry 75(4):332-41, 2014.

Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol 22 April 2014, in press.